Thyroid hormone receptor-α deletion decreases heart function
نویسندگان
چکیده
6 7 Kiao Ling Liu , Laurence Canaple , Peggy del Carmine , 8 Karine Gauthier , Michel Beylot , Ming Lo 9 10 11 12 a Neurocardiology Unit EA 4612, Institute of Pharmaceutical and Biological Sciences, 13 University Claude Bernard Lyon 1, France 14 b Institute of Functional Genomics of Lyon, University Claude Bernard Lyon 1, Centre 15 National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, France 16 c Technical Platform ANIPHY, University Claude Bernard Lyon 1, France 17
منابع مشابه
Thyroid hormone receptor-α deletion decreases heart function and exercise performance in apolipoprotein E-deficient mice.
The deletion of thyroid hormone receptor-α (TRα) in atherosclerosis-prone apolipoprotein E-deficient (ApoE(-/-)) mice (ApoE(-/-)TRα(0/0)) accelerates the formation of atherosclerotic plaques without aggravation of hypercholesterolemia. To evaluate other predisposition risk factors to atherosclerosis in this model, we studied blood pressure (BP) and cardiac and vascular functions, as well as exe...
متن کاملPHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban.
Ischemic heart disease is the leading cause of heart failure. Both clinical trials and experimental animal studies demonstrate that chronic hypoxia can induce contractile dysfunction even before substantial ventricular damage, implicating a direct role of oxygen in the regulation of cardiac contractile function. Prolyl hydroxylase domain (PHD) proteins are well recognized as oxygen sensors and ...
متن کاملNon-thyroidal illness syndrome and cardiopulmonary bypass in children with congenital heart disease
Abstract Background: The thyroid hormones influence on all metabolic pathways. After heart surgery using cardiopulmonary bypass (CPB), serum T3 decreases and remains low for at least 24 hours. Several studies on pediatric have reported reduction of thyroid hormones after heart surgery. This study aimed to investigate the status of thyroid function tests in children with CPB surgery. Metho...
متن کاملIn vivo activity of the thyroid hormone receptor beta- and α-selective agonists GC-24 and CO23 on rat liver, heart, and brain.
Thyroid hormone analogs with selective actions through specific thyroid hormone receptor (TR) subtypes are of great interest. They might offer the possibility of mimicking physiological actions of thyroid hormone with receptor subtype or tissue specificity with therapeutic aims. They are also pharmacological tools to dissect biochemical pathways mediated by specific receptor subtypes, in a comp...
متن کاملMechanism of Action of the Thyroid Hormone on the Heart
SUMMARY The foliowing cardiac effects may be attributed to thyroxin: 1-Thyroxin augments all anaerobic processes in the body includ::ng the heart, and decreases the glycogen content of the heart ( 1, 2, 5, 27). The resistance of the heart to anoxia is increased in hyperthyroidism ( 25). 2- Thyroxin influences the cardiac weight and prevents cardiac atrophy (3, 8, 10, 11, 19, 20, 21, 30...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015